Pathological intoxication1/28/2024 Most gave no specific reason for the advice. Almost all leaflets for clinicians and for patients stated in some way that alcohol should be avoided (SSRIs and venlafaxine) or used with caution (duloxetine). Table 1 presents the SPC and PIL information. We had in 2006–07 asked the UK medical directors of the main companies concerned for any information they had about possible interactions of their drug with alcohol, including experimental studies in volunteers, clinical studies, and case reports of suspected interactions. Pathological intoxication in a given individual refers to usual amounts of alcohol producing either a markedly exaggerated intoxication or qualitatively different intoxication, for example, with highly uncharacteristic disinhibition or violence Our researchįor venlafaxine, mirtazapine, bupropion, duloxetine and each of the SSRIs marketed in the UK, we examined the current summary of product characteristics (SPC) and patient information leaflet (PIL) and extracted all statements about interactions with alcohol, including warnings. With this problem in mind, we examine the warnings for patients and prescribers in company information about prescribed SSRIs and related drugs. The mechanism is not clear, but the disinhibition from alcohol together with the stimulant effect of most SSRI and related antidepressants might lead to effects not seen with either alone. 6,7 The same pattern appears across various SSRIs and venlafaxine, and in case reports from different countries, 8 but clinicians do not routinely recognise or consider it. The consequences include disinhibition of violence or sexual behaviour, sometimes with profoundly impaired memory of the event. In our practices, we have repeatedly noted that some people experience a marked change in alcohol tolerance during treatment with SSRIs and related drugs. In a subgroup of these, alcohol problems seem to become worse. 1,2 Alcohol use is common in depression, 3 but its interaction with antidepressants in patients has been little studied except in problem drinkers. The combination generally fails to impair function or produce other effects beyond those of alcohol alone. Preclinical studies of interactions between selective serotonin reuptake inhibitors (SSRIs) and alcohol have mainly been acute experiments in healthy volunteers, using various psychological performance tests. Journal of Pharmaceutical Health Services Research. International Journal of Pharmacy Practice.Antimicrobial resistance and stewardship.
0 Comments
Leave a Reply.AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |